SSRIs increasingly prescribed during pregnancy, without much study on their effects

Lead researcher Claudia Lugo-Candelas

Researchers from Columbia University, the Keck School of Medicine, and the Institute for the Developing Mind in Los Angeles, have published a new study on how infants' brains are affected when their mothers take SSRIs for depression during pregnancy. SSRIs include Celexa, Lexapro, Prozac, Luvox, Paxil and Zoloft, and are used by 1 in 10 adults in the US.

Excerpts from the study:

Selective serotonin reuptake inhibitor (SSRI) use among pregnant women is increasing, yet the association between prenatal SSRI exposure and fetal neurodevelopment is poorly understood.

A cohort study conducted at Columbia University Medical Center and New York State Psychiatric Institute included 98 infants: 16 with in utero SSRI exposure, 21 with in utero untreated maternal depression exposure, and 61 healthy controls. Our findings suggest that prenatal SSRI exposure has an association with fetal brain development, particularly in brain regions critical to emotional processing....To our knowledge, this is the first study to report increased volumes of the amygdala and insular cortex, as well as increased WM connection strength between these 2 regions, in prenatally SSRI-exposed infants.

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